Drug interactions
Danicopan + Sulphasalazine
Severity: Moderate
Danicopan and Sulphasalazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits BCRP and can raise plasma concentrations of BCRP substrates such as sulfasalazine. Higher exposure may increase the risk of sulfasalazine adverse effects.
What this interaction means in plain words
Danicopan and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Sulphasalazine belongs to Gastrointestinal Tract.
Why it happens
Danicopan inhibits BCRP, reducing efflux of sulfasalazine and increasing its systemic exposure.
What to do
Consider reducing the sulfasalazine dose in line with its labeling and monitor for GI, hematologic and hepatic adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Acetazolamide + Sulphasalazine Moderate
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Sulphasalazine?
MediHelp rates the interaction as moderate. Danicopan and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits BCRP and can raise plasma concentrations of BCRP substrates such as sulfasalazine. Higher exposure may increase the risk of sulfasalazine adverse effects.
How serious is the interaction between Danicopan and Sulphasalazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the sulfasalazine dose in line with its labeling and monitor for GI, hematologic and hepatic adverse effects.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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