Drug interactions
Danicopan + Tolvaptan
Severity: Moderate
Danicopan and Tolvaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-glycoprotein and can raise exposure to P-gp substrates such as tolvaptan. Increased tolvaptan effect may cause excessive aquaresis, dehydration or overly rapid sodium rise.
What this interaction means in plain words
Danicopan and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Tolvaptan belongs to Endocrine.
Why it happens
Danicopan inhibits intestinal and other P-gp efflux, increasing tolvaptan absorption and exposure.
What to do
Monitor serum sodium and volume status after starting danicopan. Consider lowering the tolvaptan dose if exaggerated response occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Tolvaptan?
MediHelp rates the interaction as moderate. Danicopan and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-glycoprotein and can raise exposure to P-gp substrates such as tolvaptan. Increased tolvaptan effect may cause excessive aquaresis, dehydration or overly rapid sodium rise.
How serious is the interaction between Danicopan and Tolvaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium and volume status after starting danicopan. Consider lowering the tolvaptan dose if exaggerated response occurs.
What other medicines interact with Tolvaptan?
MediHelp also lists interactions of Tolvaptan with, for example, Atazanavir, Ceritinib, Cobicistat. The full list is on the Tolvaptan page.
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