Drug interactions
Danicopan + Vincristine
Severity: Moderate
Danicopan and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-glycoprotein and can increase concentrations of its substrates, including vincristine. This may increase vincristine neurotoxicity and gastrointestinal effects.
What this interaction means in plain words
Danicopan and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Vincristine belongs to Oncology.
Why it happens
Inhibition of intestinal and cellular P-glycoprotein efflux.
What to do
Monitor for neuropathy, constipation and cytopenias. Consider vincristine dose reduction if toxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Vincristine?
MediHelp rates the interaction as moderate. Danicopan and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-glycoprotein and can increase concentrations of its substrates, including vincristine. This may increase vincristine neurotoxicity and gastrointestinal effects.
How serious is the interaction between Danicopan and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neuropathy, constipation and cytopenias. Consider vincristine dose reduction if toxicity emerges.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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