Drug interactions
Dantrolene + Diphenoxylate-atropine
Severity: Moderate
Dantrolene and Diphenoxylate-atropine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dantrolene causes drowsiness and muscle weakness, and diphenoxylate can add to central nervous system depression at higher doses. Combined use may increase sedation and impair alertness or psychomotor performance.
What this interaction means in plain words
Dantrolene and Diphenoxylate-atropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Diphenoxylate-atropine belongs to Gastrointestinal Tract.
Why it happens
Additive central nervous system depressant effects.
What to do
Use the lowest effective doses and counsel patients to avoid driving or hazardous tasks until response is known. Monitor for excessive sedation, especially in the elderly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicated
- Diphenoxylate-atropine + Phenelzine Contraindicated
- Diphenoxylate-atropine + Tranylcypromine Contraindicated
- Alfentanil + Diphenoxylate-atropine Major
- Alvimopan + Diphenoxylate-atropine Major
- Amitriptyline + Diphenoxylate-atropine Major
Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Diphenoxylate-atropine?
MediHelp rates the interaction as moderate. Dantrolene and Diphenoxylate-atropine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dantrolene causes drowsiness and muscle weakness, and diphenoxylate can add to central nervous system depression at higher doses. Combined use may increase sedation and impair alertness or psychomotor performance.
How serious is the interaction between Dantrolene and Diphenoxylate-atropine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and counsel patients to avoid driving or hazardous tasks until response is known. Monitor for excessive sedation, especially in the elderly.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
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