Drug interactions
Dantrolene + Diphenoxylate
Severity: Moderate
Dantrolene and Diphenoxylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diphenoxylate is an opioid-related antidiarrheal that can cause drowsiness and dizziness, with more significant CNS depression at higher doses. Combined with dantrolene, sedation and impaired psychomotor performance may be increased.
What this interaction means in plain words
Dantrolene and Diphenoxylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Diphenoxylate belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression from opioid-related central effects and dantrolene sedation.
What to do
Keep diphenoxylate at the recommended dose and monitor for excessive drowsiness. Counsel patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Diphenoxylate
Frequently asked questions
Can I take Dantrolene with Diphenoxylate?
MediHelp rates the interaction as moderate. Dantrolene and Diphenoxylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diphenoxylate is an opioid-related antidiarrheal that can cause drowsiness and dizziness, with more significant CNS depression at higher doses. Combined with dantrolene, sedation and impaired psychomotor performance may be increased.
How serious is the interaction between Dantrolene and Diphenoxylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep diphenoxylate at the recommended dose and monitor for excessive drowsiness. Counsel patients to avoid driving and alcohol.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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