Drug interactions
Dantrolene + Doxylamine
Severity: Moderate
Dantrolene and Doxylamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxylamine is a strongly sedating antihistamine often used as a sleep aid. With dantrolene, which also causes drowsiness, sedation and next-day impairment may be increased.
What this interaction means in plain words
Dantrolene and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Doxylamine belongs to Respiratory.
Why it happens
Additive central nervous system depression via H1-antihistamine effects and dantrolene.
What to do
Monitor for oversedation and next-day impairment, and advise against driving until the response is known. Avoid routine doxylamine use in older or frail patients on dantrolene.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Doxylamine
Frequently asked questions
Can I take Dantrolene with Doxylamine?
MediHelp rates the interaction as moderate. Dantrolene and Doxylamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxylamine is a strongly sedating antihistamine often used as a sleep aid. With dantrolene, which also causes drowsiness, sedation and next-day impairment may be increased.
How serious is the interaction between Dantrolene and Doxylamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and next-day impairment, and advise against driving until the response is known. Avoid routine doxylamine use in older or frail patients on dantrolene.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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