Drug interactions
Dantrolene + Efavirenz
Severity: Minor
Dantrolene and Efavirenz: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dantrolene is metabolised in the liver, partly by CYP3A4, and efavirenz is a moderate inducer of this enzyme. Efavirenz may lower dantrolene exposure and weaken its muscle relaxant effect, although the clinical impact has not been well characterised.
What this interaction means in plain words
Dantrolene and Efavirenz have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dantrolene belongs to Musculoskeletal; Efavirenz belongs to Anti Virals.
Why it happens
Efavirenz induction of CYP3A4 may increase dantrolene metabolism.
What to do
Monitor for reduced antispasticity effect and titrate dantrolene to response if needed. Also monitor liver function, since dantrolene is hepatotoxic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dantrolene
Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Dantrolene with Efavirenz?
MediHelp rates the interaction as minor. Dantrolene and Efavirenz have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dantrolene is metabolised in the liver, partly by CYP3A4, and efavirenz is a moderate inducer of this enzyme. Efavirenz may lower dantrolene exposure and weaken its muscle relaxant effect, although the clinical impact has not been well characterised.
How serious is the interaction between Dantrolene and Efavirenz?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antispasticity effect and titrate dantrolene to response if needed. Also monitor liver function, since dantrolene is hepatotoxic.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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