Drug interactions
Dantrolene + Imipramine
Severity: Moderate
Dantrolene and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine is a sedating tricyclic antidepressant, and dantrolene also causes drowsiness. Together they may increase sedation, dizziness and impaired coordination.
What this interaction means in plain words
Dantrolene and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Imipramine belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Monitor for oversedation, orthostatic hypotension and falls. Reduce the dose of one agent if impairment becomes significant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Dantrolene with Imipramine?
MediHelp rates the interaction as moderate. Dantrolene and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imipramine is a sedating tricyclic antidepressant, and dantrolene also causes drowsiness. Together they may increase sedation, dizziness and impaired coordination.
How serious is the interaction between Dantrolene and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, orthostatic hypotension and falls. Reduce the dose of one agent if impairment becomes significant.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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