Drug interactions
Dantrolene + Istradefylline
Severity: Minor
Dantrolene and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg daily istradefylline weakly inhibits CYP3A4 and may increase exposure to CYP3A4 substrates such as dantrolene. Increased dantrolene levels could heighten sedation, weakness and hepatotoxicity risk.
What this interaction means in plain words
Dantrolene and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dantrolene belongs to Musculoskeletal; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline inhibits CYP3A4 at higher doses, reducing dantrolene metabolism.
What to do
Monitor for dantrolene adverse effects and liver function when istradefylline 40 mg is used, and lower the dantrolene dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dantrolene
Other interactions of Istradefylline
Frequently asked questions
Can I take Dantrolene with Istradefylline?
MediHelp rates the interaction as minor. Dantrolene and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At 40 mg daily istradefylline weakly inhibits CYP3A4 and may increase exposure to CYP3A4 substrates such as dantrolene. Increased dantrolene levels could heighten sedation, weakness and hepatotoxicity risk.
How serious is the interaction between Dantrolene and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dantrolene adverse effects and liver function when istradefylline 40 mg is used, and lower the dantrolene dose if needed.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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