Drug interactions
Dantrolene + Ivosidenib
Severity: Moderate
Dantrolene and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib is a CYP3A4 inducer and may lower dantrolene concentrations, potentially reducing its effect. The effect is predicted from the mechanism and is not well documented clinically.
What this interaction means in plain words
Dantrolene and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Ivosidenib belongs to Oncology.
Why it happens
Ivosidenib induction of CYP3A4 may increase dantrolene metabolism.
What to do
Monitor for loss of dantrolene effect and titrate dose accordingly. Consider an alternative if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Dantrolene with Ivosidenib?
MediHelp rates the interaction as moderate. Dantrolene and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib is a CYP3A4 inducer and may lower dantrolene concentrations, potentially reducing its effect. The effect is predicted from the mechanism and is not well documented clinically.
How serious is the interaction between Dantrolene and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of dantrolene effect and titrate dose accordingly. Consider an alternative if response is inadequate.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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