Drug interactions
Dantrolene + Larotrectinib
Severity: Minor
Dantrolene and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate that may weakly inhibit CYP3A4, so it could slightly raise dantrolene levels. Clinical significance is likely small, but dantrolene has dose-related liver toxicity.
What this interaction means in plain words
Dantrolene and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dantrolene belongs to Musculoskeletal; Larotrectinib belongs to Oncology.
Why it happens
Possible weak CYP3A4 inhibition reducing dantrolene clearance; the effect is predicted rather than well documented.
What to do
No routine dose change is needed. Monitor liver enzymes and muscle weakness during combined use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dantrolene
Other interactions of Larotrectinib
Frequently asked questions
Can I take Dantrolene with Larotrectinib?
MediHelp rates the interaction as minor. Dantrolene and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate that may weakly inhibit CYP3A4, so it could slightly raise dantrolene levels. Clinical significance is likely small, but dantrolene has dose-related liver toxicity.
How serious is the interaction between Dantrolene and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor liver enzymes and muscle weakness during combined use.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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