Drug interactions
Dantrolene + Lorazepam
Severity: Moderate
Dantrolene and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorazepam is a benzodiazepine that causes sedation and psychomotor impairment, and dantrolene adds drowsiness. Together they can increase central nervous system depression and the risk of falls.
What this interaction means in plain words
Dantrolene and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Lorazepam belongs to Central Nervous System.
Why it happens
Additive central nervous system depression via GABA-A enhancement and dantrolene's sedative effect.
What to do
Use the lowest effective doses and monitor for oversedation and impaired coordination. Advise against alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Lorazepam
Frequently asked questions
Can I take Dantrolene with Lorazepam?
MediHelp rates the interaction as moderate. Dantrolene and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorazepam is a benzodiazepine that causes sedation and psychomotor impairment, and dantrolene adds drowsiness. Together they can increase central nervous system depression and the risk of falls.
How serious is the interaction between Dantrolene and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation and impaired coordination. Advise against alcohol and driving.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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