Drug interactions
Dantrolene + Methadone
Severity: Moderate
Dantrolene and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dantrolene can cause drowsiness and dizziness, which add to the sedative effects of methadone. The combination may increase impairment and the risk of respiratory depression.
What this interaction means in plain words
Dantrolene and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Methadone belongs to Musculoskeletal.
Why it happens
Additive CNS depression.
What to do
Counsel the patient about sedation and avoiding driving or hazardous tasks. Monitor for excessive drowsiness and adjust doses accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Methadone?
MediHelp rates the interaction as moderate. Dantrolene and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dantrolene can cause drowsiness and dizziness, which add to the sedative effects of methadone. The combination may increase impairment and the risk of respiratory depression.
How serious is the interaction between Dantrolene and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about sedation and avoiding driving or hazardous tasks. Monitor for excessive drowsiness and adjust doses accordingly.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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