Drug interactions
Dantrolene + Morphine
Severity: Moderate
Dantrolene and Morphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dantrolene can cause drowsiness, dizziness and generalized weakness, which may add to morphine's sedative effects. Oral dantrolene may also weaken respiratory muscles.
What this interaction means in plain words
Dantrolene and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Morphine belongs to Musculoskeletal.
Why it happens
Additive CNS depression and skeletal muscle weakness.
What to do
Monitor sedation and respiratory function, and counsel patients about driving and operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Morphine?
MediHelp rates the interaction as moderate. Dantrolene and Morphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dantrolene can cause drowsiness, dizziness and generalized weakness, which may add to morphine's sedative effects. Oral dantrolene may also weaken respiratory muscles.
How serious is the interaction between Dantrolene and Morphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory function, and counsel patients about driving and operating machinery.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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