Drug interactions
Dantrolene + Primidone
Severity: Moderate
Dantrolene and Primidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is metabolized to phenobarbital, an inducer of CYP3A4, so it may reduce dantrolene exposure and effect. Additive sedation can also occur, and the clinical data are limited.
What this interaction means in plain words
Dantrolene and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Primidone belongs to Central Nervous System.
Why it happens
Enzyme induction by primidone and its metabolite phenobarbital may increase dantrolene metabolism; additive CNS depression.
What to do
Monitor clinical response and liver function tests, and titrate dantrolene to effect. Watch for additive sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Dantrolene with Primidone?
MediHelp rates the interaction as moderate. Dantrolene and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone is metabolized to phenobarbital, an inducer of CYP3A4, so it may reduce dantrolene exposure and effect. Additive sedation can also occur, and the clinical data are limited.
How serious is the interaction between Dantrolene and Primidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and liver function tests, and titrate dantrolene to effect. Watch for additive sedation.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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