Drug interactions
Dantrolene + Rifabutin
Severity: Moderate
Dantrolene and Rifabutin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin induces CYP3A4, and dantrolene is metabolized in the liver, so exposure to dantrolene could fall. This may reduce its antispasticity effect, though the clinical significance is not well documented.
What this interaction means in plain words
Dantrolene and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Rifabutin belongs to Anti Bacterial.
Why it happens
Induction of hepatic CYP3A4 by rifabutin may increase dantrolene clearance.
What to do
Monitor spasticity control and increase the dantrolene dose if needed, within limits and with liver function checks. Reassess the dose when rifabutin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Dantrolene with Rifabutin?
MediHelp rates the interaction as moderate. Dantrolene and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin induces CYP3A4, and dantrolene is metabolized in the liver, so exposure to dantrolene could fall. This may reduce its antispasticity effect, though the clinical significance is not well documented.
How serious is the interaction between Dantrolene and Rifabutin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor spasticity control and increase the dantrolene dose if needed, within limits and with liver function checks. Reassess the dose when rifabutin is stopped.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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