Drug interactions
Dapagliflozin + Dulaglutide
Severity: Minor
Dapagliflozin and Dulaglutide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dulaglutide and dapagliflozin are commonly combined for additive glycemic and weight benefit. Hypoglycemia is rare unless insulin or a sulfonylurea is also used. Gastrointestinal fluid loss from dulaglutide can add to the diuretic effect of dapagliflozin.
What this interaction means in plain words
Dapagliflozin and Dulaglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapagliflozin belongs to Endocrine; Dulaglutide belongs to Endocrine.
Why it happens
Complementary mechanisms: incretin-mediated insulin secretion plus SGLT2-mediated urinary glucose excretion.
What to do
Monitor glucose and volume status, particularly during gastrointestinal illness. Lower any concurrent insulin or sulfonylurea dose when starting.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dulaglutide
Other interactions of Dapagliflozin
- Chlorpropamide + Dapagliflozin Moderate
- Dapagliflozin + Gliclazide Moderate
- Dapagliflozin + Glimepiride Moderate
- Dapagliflozin + Glimepiride-pioglitazone Moderate
- Dapagliflozin + Glipizide Moderate
- Dapagliflozin + Glipizide-metformin Moderate
Frequently asked questions
Can I take Dapagliflozin with Dulaglutide?
MediHelp rates the interaction as minor. Dapagliflozin and Dulaglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dulaglutide and dapagliflozin are commonly combined for additive glycemic and weight benefit. Hypoglycemia is rare unless insulin or a sulfonylurea is also used. Gastrointestinal fluid loss from dulaglutide can add to the diuretic effect of dapagliflozin.
How serious is the interaction between Dapagliflozin and Dulaglutide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and volume status, particularly during gastrointestinal illness. Lower any concurrent insulin or sulfonylurea dose when starting.
What other medicines interact with Dulaglutide?
MediHelp also lists interactions of Dulaglutide with, for example, Insulin degludec-liraglutide, Insulin glargine-lixisenatide, Alogliptin-metformin. The full list is on the Dulaglutide page.
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