Drug interactions
Dapagliflozin + Repaglinide
Severity: Moderate
Dapagliflozin and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dapagliflozin added to repaglinide increases hypoglycemia risk. A lower dose of the insulin secretagogue may be needed.
What this interaction means in plain words
Dapagliflozin and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin belongs to Endocrine; Repaglinide belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose lowering from SGLT2 inhibition and insulin secretagogue action.
What to do
Consider lowering the repaglinide dose when starting dapagliflozin. Monitor blood glucose and counsel on hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Other interactions of Dapagliflozin
- Chlorpropamide + Dapagliflozin Moderate
- Dapagliflozin + Gliclazide Moderate
- Dapagliflozin + Glimepiride Moderate
- Dapagliflozin + Glimepiride-pioglitazone Moderate
- Dapagliflozin + Glipizide Moderate
- Dapagliflozin + Glipizide-metformin Moderate
Frequently asked questions
Can I take Dapagliflozin with Repaglinide?
MediHelp rates the interaction as moderate. Dapagliflozin and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapagliflozin added to repaglinide increases hypoglycemia risk. A lower dose of the insulin secretagogue may be needed.
How serious is the interaction between Dapagliflozin and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the repaglinide dose when starting dapagliflozin. Monitor blood glucose and counsel on hypoglycemia.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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