Drug interactions
Dapagliflozin-metformin + Darunavir
Severity: Moderate
Dapagliflozin-metformin and Darunavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protease inhibitors such as darunavir can cause insulin resistance and hyperglycemia, which may reduce the effectiveness of antidiabetic therapy. Glucose control may worsen after darunavir is started.
What this interaction means in plain words
Dapagliflozin-metformin and Darunavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Darunavir belongs to Anti Virals.
Why it happens
Protease inhibitors can impair insulin sensitivity and glucose uptake, opposing the effect of the antidiabetic drugs.
What to do
Monitor blood glucose after darunavir is started or stopped. Titrate the antidiabetic regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Dapagliflozin-metformin with Darunavir?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Darunavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protease inhibitors such as darunavir can cause insulin resistance and hyperglycemia, which may reduce the effectiveness of antidiabetic therapy. Glucose control may worsen after darunavir is started.
How serious is the interaction between Dapagliflozin-metformin and Darunavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after darunavir is started or stopped. Titrate the antidiabetic regimen as needed.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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