Drug interactions
Dapagliflozin-metformin + Ethacrynic acid
Severity: Moderate
Dapagliflozin-metformin and Ethacrynic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics may raise blood glucose in some patients, which can slightly weaken glycemic control. Diuretic-induced volume depletion can also add to the volume-related effects of dapagliflozin and affect renal function and metformin safety.
What this interaction means in plain words
Dapagliflozin-metformin and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Ethacrynic acid belongs to Cardiovascular.
Why it happens
Loop diuretics can impair glucose tolerance, and the additive diuresis with dapagliflozin increases volume depletion risk.
What to do
Monitor blood glucose, volume status and renal function. Adjust diuretic or antidiabetic doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Dapagliflozin-metformin with Ethacrynic acid?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics may raise blood glucose in some patients, which can slightly weaken glycemic control. Diuretic-induced volume depletion can also add to the volume-related effects of dapagliflozin and affect renal function and metformin safety.
How serious is the interaction between Dapagliflozin-metformin and Ethacrynic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, volume status and renal function. Adjust diuretic or antidiabetic doses as needed.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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