Drug interactions
Dapagliflozin-metformin + Fluphenazine
Severity: Moderate
Dapagliflozin-metformin and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazine antipsychotics can raise blood glucose and impair glucose tolerance, although fluphenazine has a lower metabolic risk than many atypical antipsychotics. This may reduce the effect of the antidiabetic combination.
What this interaction means in plain words
Dapagliflozin-metformin and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Fluphenazine belongs to Central Nervous System.
Why it happens
Dopamine and other receptor antagonism may reduce insulin secretion and sensitivity, antagonizing glucose-lowering effects.
What to do
Monitor fasting glucose and HbA1c after starting or changing fluphenazine, and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Dapagliflozin-metformin with Fluphenazine?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazine antipsychotics can raise blood glucose and impair glucose tolerance, although fluphenazine has a lower metabolic risk than many atypical antipsychotics. This may reduce the effect of the antidiabetic combination.
How serious is the interaction between Dapagliflozin-metformin and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after starting or changing fluphenazine, and adjust antidiabetic therapy if control worsens.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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