Drug interactions
Dapagliflozin-metformin + Furosemide
Severity: Moderate
Dapagliflozin-metformin and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide can raise metformin concentrations, while metformin may modestly lower furosemide levels. Loop diuretics may also cause volume depletion and renal impairment, which increases the risk of metformin accumulation and lactic acidosis, and dapagliflozin adds to diuresis.
What this interaction means in plain words
Dapagliflozin-metformin and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Furosemide belongs to Cardiovascular.
Why it happens
Furosemide alters metformin pharmacokinetics, possibly through renal transport effects, and diuretic-induced volume depletion reduces renal clearance; dapagliflozin adds osmotic diuresis.
What to do
Monitor renal function, hydration status and blood glucose; consider reducing the diuretic dose if volume depletion develops and hold metformin if renal function deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Dapagliflozin-metformin with Furosemide?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Furosemide can raise metformin concentrations, while metformin may modestly lower furosemide levels. Loop diuretics may also cause volume depletion and renal impairment, which increases the risk of metformin accumulation and lactic acidosis, and dapagliflozin adds to diuresis.
How serious is the interaction between Dapagliflozin-metformin and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, hydration status and blood glucose; consider reducing the diuretic dose if volume depletion develops and hold metformin if renal function deteriorates.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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