Drug interactions
Dapagliflozin-metformin + Iloperidone
Severity: Moderate
Dapagliflozin-metformin and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics such as iloperidone are associated with hyperglycemia and metabolic disturbance, which may weaken glycemic control. Weight gain can add to the effect.
What this interaction means in plain words
Dapagliflozin-metformin and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Iloperidone belongs to Central Nervous System.
Why it happens
Antipsychotic-related insulin resistance and weight gain oppose the antidiabetic drugs.
What to do
Monitor blood glucose, HbA1c and weight regularly. Intensify antidiabetic therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Dapagliflozin-metformin with Iloperidone?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atypical antipsychotics such as iloperidone are associated with hyperglycemia and metabolic disturbance, which may weaken glycemic control. Weight gain can add to the effect.
How serious is the interaction between Dapagliflozin-metformin and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, HbA1c and weight regularly. Intensify antidiabetic therapy if control worsens.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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