Drug interactions
Dapagliflozin-metformin + Imidapril
Severity: Moderate
Dapagliflozin-metformin and Imidapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may enhance insulin sensitivity and glucose lowering. Combined with dapagliflozin's volume effects, they may reduce renal function and promote metformin accumulation.
What this interaction means in plain words
Dapagliflozin-metformin and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Imidapril belongs to Cardiovascular.
Why it happens
ACE inhibition may increase insulin sensitivity, and combined hemodynamic effects with SGLT2 inhibition may reduce renal function and metformin clearance.
What to do
Monitor renal function, hydration and glucose, particularly at initiation; hold metformin during acute kidney injury or dehydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Dapagliflozin-metformin with Imidapril?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may enhance insulin sensitivity and glucose lowering. Combined with dapagliflozin's volume effects, they may reduce renal function and promote metformin accumulation.
How serious is the interaction between Dapagliflozin-metformin and Imidapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, hydration and glucose, particularly at initiation; hold metformin during acute kidney injury or dehydration.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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