Drug interactions
Dapagliflozin-metformin + Insulin glargine
Severity: Moderate
Dapagliflozin-metformin and Insulin glargine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding dapagliflozin and metformin to insulin increases the glucose-lowering effect and the risk of hypoglycemia. Dapagliflozin with insulin also carries a risk of ketoacidosis if insulin doses are reduced too far.
What this interaction means in plain words
Dapagliflozin-metformin and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Insulin glargine belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose lowering through insulin action, reduced hepatic glucose output and urinary glucose excretion.
What to do
Consider reducing the basal insulin dose when starting the combination and monitor glucose closely; avoid excessive insulin reduction and check ketones if the patient is unwell.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Insulin glargine
Frequently asked questions
Can I take Dapagliflozin-metformin with Insulin glargine?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding dapagliflozin and metformin to insulin increases the glucose-lowering effect and the risk of hypoglycemia. Dapagliflozin with insulin also carries a risk of ketoacidosis if insulin doses are reduced too far.
How serious is the interaction between Dapagliflozin-metformin and Insulin glargine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the basal insulin dose when starting the combination and monitor glucose closely; avoid excessive insulin reduction and check ketones if the patient is unwell.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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