Drug interactions
Dapagliflozin-metformin + Liraglutide
Severity: Minor
Dapagliflozin-metformin and Liraglutide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Liraglutide with dapagliflozin and metformin gives additive glucose and weight lowering, which is often intended. Hypoglycemia is uncommon unless insulin or a sulfonylurea is also used, and volume depletion from vomiting or diarrhea may add to dapagliflozin's diuretic effect.
What this interaction means in plain words
Dapagliflozin-metformin and Liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapagliflozin-metformin belongs to Endocrine; Liraglutide belongs to Endocrine.
Why it happens
Complementary mechanisms of glucose lowering: GLP-1 receptor agonism, SGLT2 inhibition and reduced hepatic glucose production.
What to do
Monitor glucose and hydration, particularly if gastrointestinal side effects occur; reduce any concurrent insulin or sulfonylurea if hypoglycemia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Other interactions of Liraglutide
Frequently asked questions
Can I take Dapagliflozin-metformin with Liraglutide?
MediHelp rates the interaction as minor. Dapagliflozin-metformin and Liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Liraglutide with dapagliflozin and metformin gives additive glucose and weight lowering, which is often intended. Hypoglycemia is uncommon unless insulin or a sulfonylurea is also used, and volume depletion from vomiting or diarrhea may add to dapagliflozin's diuretic effect.
How serious is the interaction between Dapagliflozin-metformin and Liraglutide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and hydration, particularly if gastrointestinal side effects occur; reduce any concurrent insulin or sulfonylurea if hypoglycemia develops.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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