Drug interactions
Dapagliflozin-metformin + Lurasidone
Severity: Minor
Dapagliflozin-metformin and Lurasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics can cause hyperglycemia and metabolic disturbance, which may counteract the glucose-lowering effect of the antidiabetic combination. Lurasidone has a relatively small metabolic effect compared with other agents in its class, but glycemic control can still shift.
What this interaction means in plain words
Dapagliflozin-metformin and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapagliflozin-metformin belongs to Endocrine; Lurasidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism through antipsychotic-related insulin resistance and impaired glucose regulation.
What to do
Monitor fasting glucose and HbA1c after starting lurasidone and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Dapagliflozin-metformin with Lurasidone?
MediHelp rates the interaction as minor. Dapagliflozin-metformin and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atypical antipsychotics can cause hyperglycemia and metabolic disturbance, which may counteract the glucose-lowering effect of the antidiabetic combination. Lurasidone has a relatively small metabolic effect compared with other agents in its class, but glycemic control can still shift.
How serious is the interaction between Dapagliflozin-metformin and Lurasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after starting lurasidone and adjust antidiabetic therapy if control worsens.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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