Drug interactions
Dapagliflozin-metformin + Memantine
Severity: Minor
Dapagliflozin-metformin and Memantine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Memantine is a cationic drug eliminated partly by tubular secretion and could compete with metformin for renal transport. Clinically significant changes in metformin exposure are not well documented.
What this interaction means in plain words
Dapagliflozin-metformin and Memantine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapagliflozin-metformin belongs to Endocrine; Memantine belongs to Central Nervous System.
Why it happens
Possible competition for renal tubular cationic transport (OCT2/MATE) reduces clearance of either drug.
What to do
No dose change usually needed; monitor renal function and glycemic response, especially in older patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Other interactions of Memantine
- Ketamine + Memantine Major
- Acetazolamide + Memantine Moderate
- Aluminum hydroxide + Memantine Moderate
- Amantadine + Memantine Moderate
- Dextromethorphan + Memantine Moderate
- Dofetilide + Memantine Moderate
Frequently asked questions
Can I take Dapagliflozin-metformin with Memantine?
MediHelp rates the interaction as minor. Dapagliflozin-metformin and Memantine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Memantine is a cationic drug eliminated partly by tubular secretion and could compete with metformin for renal transport. Clinically significant changes in metformin exposure are not well documented.
How serious is the interaction between Dapagliflozin-metformin and Memantine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change usually needed; monitor renal function and glycemic response, especially in older patients.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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