Drug interactions
Dapagliflozin-metformin + Moxifloxacin
Severity: Moderate
Dapagliflozin-metformin and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients taking antidiabetic drugs, particularly older adults and those with renal impairment. Moxifloxacin carries a lower risk than some other quinolones, but glucose disturbances remain possible.
What this interaction means in plain words
Dapagliflozin-metformin and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolones affect pancreatic beta-cell potassium channels, altering insulin secretion and causing dysglycemia.
What to do
Monitor blood glucose during the antibiotic course and counsel the patient on hypoglycemia symptoms. Stop the quinolone and treat if significant dysglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Dapagliflozin-metformin with Moxifloxacin?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients taking antidiabetic drugs, particularly older adults and those with renal impairment. Moxifloxacin carries a lower risk than some other quinolones, but glucose disturbances remain possible.
How serious is the interaction between Dapagliflozin-metformin and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during the antibiotic course and counsel the patient on hypoglycemia symptoms. Stop the quinolone and treat if significant dysglycemia occurs.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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