Drug interactions
Dapagliflozin-metformin + Perphenazine
Severity: Minor
Dapagliflozin-metformin and Perphenazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazine antipsychotics may raise blood glucose and impair glucose tolerance, which can reduce the effect of antidiabetic therapy. The effect is generally modest with perphenazine.
What this interaction means in plain words
Dapagliflozin-metformin and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapagliflozin-metformin belongs to Endocrine; Perphenazine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism through antipsychotic-related insulin resistance and reduced insulin secretion.
What to do
Monitor glucose when starting or stopping perphenazine and adjust antidiabetic therapy if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Dapagliflozin-metformin with Perphenazine?
MediHelp rates the interaction as minor. Dapagliflozin-metformin and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenothiazine antipsychotics may raise blood glucose and impair glucose tolerance, which can reduce the effect of antidiabetic therapy. The effect is generally modest with perphenazine.
How serious is the interaction between Dapagliflozin-metformin and Perphenazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when starting or stopping perphenazine and adjust antidiabetic therapy if control changes.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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