Drug interactions
Dapagliflozin-metformin + Sirolimus
Severity: Moderate
Dapagliflozin-metformin and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus commonly causes hyperglycaemia, insulin resistance and new-onset diabetes, which may reduce glycaemic control with dapagliflozin-metformin. It also impairs renal function in some patients, which matters for metformin safety.
What this interaction means in plain words
Dapagliflozin-metformin and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Sirolimus belongs to Miscellaneous.
Why it happens
mTOR inhibition reduces insulin signalling and beta-cell function, opposing antidiabetic drug effects (pharmacodynamic antagonism).
What to do
Monitor glucose, HbA1c and renal function during sirolimus therapy. Intensify antidiabetic treatment as needed and review metformin if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Dapagliflozin-metformin with Sirolimus?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sirolimus commonly causes hyperglycaemia, insulin resistance and new-onset diabetes, which may reduce glycaemic control with dapagliflozin-metformin. It also impairs renal function in some patients, which matters for metformin safety.
How serious is the interaction between Dapagliflozin-metformin and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose, HbA1c and renal function during sirolimus therapy. Intensify antidiabetic treatment as needed and review metformin if renal function declines.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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