Drug interactions
Dapsone + Lapatinib
Severity: Minor
Dapsone and Lapatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib inhibits CYP3A4 and could theoretically raise dapsone concentrations. Higher dapsone exposure could increase dose-related hemolysis and methemoglobinemia, although clinical data are lacking.
What this interaction means in plain words
Dapsone and Lapatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dapsone belongs to Anti Bacterial; Lapatinib belongs to Oncology.
Why it happens
Theoretical inhibition of CYP3A4-mediated dapsone N-hydroxylation by lapatinib.
What to do
Monitor hemoglobin and methemoglobin symptoms (cyanosis, dyspnea) if combined for a prolonged period.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Dapsone with Lapatinib?
MediHelp rates the interaction as minor. Dapsone and Lapatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lapatinib inhibits CYP3A4 and could theoretically raise dapsone concentrations. Higher dapsone exposure could increase dose-related hemolysis and methemoglobinemia, although clinical data are lacking.
How serious is the interaction between Dapsone and Lapatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and methemoglobin symptoms (cyanosis, dyspnea) if combined for a prolonged period.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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