Drug interactions
Dapsone + Mifepristone
Severity: Moderate
Dapsone and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may raise dapsone levels. Both drugs can contribute to methaemoglobinaemia or haemolysis risk in susceptible patients, particularly with G6PD deficiency.
What this interaction means in plain words
Dapsone and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapsone belongs to Anti Bacterial; Mifepristone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 (and CYP2C8/2C9) by mifepristone reduces dapsone clearance.
What to do
Monitor haemoglobin and methaemoglobin levels, and check G6PD status before use together.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Dapsone with Mifepristone?
MediHelp rates the interaction as moderate. Dapsone and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and may raise dapsone levels. Both drugs can contribute to methaemoglobinaemia or haemolysis risk in susceptible patients, particularly with G6PD deficiency.
How serious is the interaction between Dapsone and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor haemoglobin and methaemoglobin levels, and check G6PD status before use together.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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