Drug interactions
Dapsone + Rifapentine
Severity: Moderate
Dapsone and Rifapentine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine induces hepatic enzymes and can reduce dapsone concentrations, as seen with rifampin. Lower exposure may compromise efficacy, for example in prophylaxis or leprosy regimens.
What this interaction means in plain words
Dapsone and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapsone belongs to Anti Bacterial; Rifapentine belongs to Anti Bacterial.
Why it happens
Rifapentine induces CYP3A4 and other metabolizing enzymes, increasing dapsone clearance.
What to do
Monitor clinical response and consider a higher dapsone dose or alternative prophylaxis if efficacy is a concern. Reassess dosing after rifapentine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Dapsone with Rifapentine?
MediHelp rates the interaction as moderate. Dapsone and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine induces hepatic enzymes and can reduce dapsone concentrations, as seen with rifampin. Lower exposure may compromise efficacy, for example in prophylaxis or leprosy regimens.
How serious is the interaction between Dapsone and Rifapentine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and consider a higher dapsone dose or alternative prophylaxis if efficacy is a concern. Reassess dosing after rifapentine is stopped.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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