Drug interactions
Dapsone + Voxelotor
Severity: Moderate
Dapsone and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 and can raise exposure to sensitive CYP3A4 substrates. Dapsone is partly metabolized by CYP3A4 (and N-acetylation/CYP2C9), so higher levels could increase dose-related hematologic toxicity such as methemoglobinemia and hemolysis. The clinical significance for dapsone is uncertain and probably modest.
What this interaction means in plain words
Dapsone and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapsone belongs to Anti Bacterial; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibits intestinal and hepatic CYP3A4, reducing the oxidative metabolism of dapsone.
What to do
Monitor for methemoglobinemia, hemolysis and anemia with a CBC, and reduce the dapsone dose if toxicity appears. Consider an alternative if dapsone is used at high doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Dapsone with Voxelotor?
MediHelp rates the interaction as moderate. Dapsone and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor inhibits CYP3A4 and can raise exposure to sensitive CYP3A4 substrates. Dapsone is partly metabolized by CYP3A4 (and N-acetylation/CYP2C9), so higher levels could increase dose-related hematologic toxicity such as methemoglobinemia and hemolysis. The clinical significance for dapsone is uncertain and probably modest.
How serious is the interaction between Dapsone and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for methemoglobinemia, hemolysis and anemia with a CBC, and reduce the dapsone dose if toxicity appears. Consider an alternative if dapsone is used at high doses.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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