Drug interactions
Daptomycin + Pitavastatin
Severity: Moderate
Daptomycin and Pitavastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both daptomycin and statins can cause skeletal muscle injury, so using them together may increase the risk of myopathy and rhabdomyolysis with CPK elevation. The risk is additive rather than pharmacokinetic.
What this interaction means in plain words
Daptomycin and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daptomycin belongs to Anti Bacterial; Pitavastatin belongs to Cardiovascular.
Why it happens
Additive myotoxicity of daptomycin and HMG-CoA reductase inhibitors; the mechanism is not fully established.
What to do
Monitor CPK weekly and for muscle symptoms during daptomycin therapy. Consider temporarily withholding pitavastatin if myopathy is suspected or CPK rises markedly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pitavastatin
- Cyclosporine + Pitavastatin Contraindicated
- Cyclosporin + Pitavastatin Contraindicated
- Erythromycin base + Pitavastatin Major
- Erythromycin ethylsuccinate + Pitavastatin Major
- Erythromycin lactobionate + Pitavastatin Major
- Erythromycin stearate + Pitavastatin Major
Other interactions of Daptomycin
- Daptomycin + Simvastatin Major
- Atorvastatin + Daptomycin Moderate
- Daptomycin + Fluvastatin Moderate
- Daptomycin + Lovastatin Moderate
- Daptomycin + Pravastatin Moderate
- Daptomycin + Rosuvastatin Moderate
Frequently asked questions
Can I take Daptomycin with Pitavastatin?
MediHelp rates the interaction as moderate. Daptomycin and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both daptomycin and statins can cause skeletal muscle injury, so using them together may increase the risk of myopathy and rhabdomyolysis with CPK elevation. The risk is additive rather than pharmacokinetic.
How serious is the interaction between Daptomycin and Pitavastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor CPK weekly and for muscle symptoms during daptomycin therapy. Consider temporarily withholding pitavastatin if myopathy is suspected or CPK rises markedly.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporine, Cyclosporin, Erythromycin base. The full list is on the Pitavastatin page.
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