Drug interactions
Daptomycin + Rosuvastatin
Severity: Moderate
Daptomycin and Rosuvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Daptomycin can cause myopathy and CPK elevation, and statins carry a similar risk, so combined use may raise the chance of muscle toxicity. Case reports and labeling describe this concern, although controlled data are limited.
What this interaction means in plain words
Daptomycin and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daptomycin belongs to Anti Bacterial; Rosuvastatin belongs to Cardiovascular.
Why it happens
Additive skeletal muscle toxicity; the mechanism is not fully established.
What to do
Consider holding rosuvastatin during daptomycin therapy if clinically acceptable. If it is continued, monitor CPK weekly and for muscle pain or weakness, and stop daptomycin if myopathy develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosuvastatin
Other interactions of Daptomycin
- Daptomycin + Simvastatin Major
- Atorvastatin + Daptomycin Moderate
- Daptomycin + Fluvastatin Moderate
- Daptomycin + Lovastatin Moderate
- Daptomycin + Pitavastatin Moderate
- Daptomycin + Pravastatin Moderate
Frequently asked questions
Can I take Daptomycin with Rosuvastatin?
MediHelp rates the interaction as moderate. Daptomycin and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Daptomycin can cause myopathy and CPK elevation, and statins carry a similar risk, so combined use may raise the chance of muscle toxicity. Case reports and labeling describe this concern, although controlled data are limited.
How serious is the interaction between Daptomycin and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider holding rosuvastatin during daptomycin therapy if clinically acceptable. If it is continued, monitor CPK weekly and for muscle pain or weakness, and stop daptomycin if myopathy develops.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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