Drug interactions
daptomycin + simvastatin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↑ myopathy/CK elevation risk.
Mechanism of action
Additive muscle toxicity.
Clinical management
Consider holding statin during dapto; monitor CK.
Drug reference
References
Frequently asked questions
Can I take daptomycin with simvastatin?
The interaction is rated: Major. ↑ myopathy/CK elevation risk.
How serious is the interaction between daptomycin and simvastatin?
The interaction is rated: Major. Evidence level: Moderate.
How is the interaction between daptomycin and simvastatin managed?
Consider holding statin during dapto; monitor CK.
Why do daptomycin and simvastatin interact?
Additive muscle toxicity.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.