Drug interactions
Atorvastatin + Daptomycin
Severity: Moderate
Atorvastatin and Daptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Daptomycin can cause myopathy and CPK elevation, and statins carry a similar risk, so combined use may raise the chance of muscle toxicity. Case reports and labeling describe this concern, although controlled data are limited.
What this interaction means in plain words
Atorvastatin and Daptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Daptomycin belongs to Anti Bacterial.
Why it happens
Additive skeletal muscle toxicity; the mechanism is not fully established.
What to do
Consider holding the statin during daptomycin therapy if clinically acceptable. If it is continued, monitor CPK weekly and for muscle pain or weakness, and stop daptomycin if myopathy develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Cyclosporine Major
Other interactions of Daptomycin
- Daptomycin + Simvastatin Major
- Daptomycin + Fluvastatin Moderate
- Daptomycin + Lovastatin Moderate
- Daptomycin + Pitavastatin Moderate
- Daptomycin + Pravastatin Moderate
- Daptomycin + Rosuvastatin Moderate
Frequently asked questions
Can I take Atorvastatin with Daptomycin?
MediHelp rates the interaction as moderate. Atorvastatin and Daptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Daptomycin can cause myopathy and CPK elevation, and statins carry a similar risk, so combined use may raise the chance of muscle toxicity. Case reports and labeling describe this concern, although controlled data are limited.
How serious is the interaction between Atorvastatin and Daptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider holding the statin during daptomycin therapy if clinically acceptable. If it is continued, monitor CPK weekly and for muscle pain or weakness, and stop daptomycin if myopathy develops.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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