Drug interactions
Daptomycin + Pravastatin
Severity: Moderate
Daptomycin and Pravastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both daptomycin and statins can cause skeletal muscle injury, so using them together may increase the risk of myopathy and rhabdomyolysis with CPK elevation. The risk is additive rather than pharmacokinetic.
What this interaction means in plain words
Daptomycin and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daptomycin belongs to Anti Bacterial; Pravastatin belongs to Cardiovascular.
Why it happens
Additive myotoxicity of daptomycin and HMG-CoA reductase inhibitors; the mechanism is not fully established.
What to do
Monitor CPK weekly and for muscle symptoms during daptomycin therapy. Consider temporarily withholding pravastatin if myopathy is suspected or CPK rises markedly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pravastatin
Other interactions of Daptomycin
- Daptomycin + Simvastatin Major
- Atorvastatin + Daptomycin Moderate
- Daptomycin + Fluvastatin Moderate
- Daptomycin + Lovastatin Moderate
- Daptomycin + Pitavastatin Moderate
- Daptomycin + Rosuvastatin Moderate
Frequently asked questions
Can I take Daptomycin with Pravastatin?
MediHelp rates the interaction as moderate. Daptomycin and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both daptomycin and statins can cause skeletal muscle injury, so using them together may increase the risk of myopathy and rhabdomyolysis with CPK elevation. The risk is additive rather than pharmacokinetic.
How serious is the interaction between Daptomycin and Pravastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor CPK weekly and for muscle symptoms during daptomycin therapy. Consider temporarily withholding pravastatin if myopathy is suspected or CPK rises markedly.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Pravastatin page.
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