Drug interactions
Daptomycin + Lovastatin
Severity: Moderate
Daptomycin and Lovastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Daptomycin can raise creatine phosphokinase and cause myopathy or rhabdomyolysis, and statins carry the same risk. Using both together may increase the likelihood of muscle toxicity.
What this interaction means in plain words
Daptomycin and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daptomycin belongs to Anti Bacterial; Lovastatin belongs to Cardiovascular.
Why it happens
Additive skeletal muscle toxicity from both drugs; no pharmacokinetic interaction is established.
What to do
Consider temporarily withholding lovastatin during daptomycin therapy, especially in patients with renal impairment or other risk factors. If both are continued, monitor CPK weekly and assess for muscle pain or weakness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Daptomycin and Lovastatin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Other interactions of Daptomycin
- Daptomycin + Simvastatin Major
- Atorvastatin + Daptomycin Moderate
- Daptomycin + Fluvastatin Moderate
- Daptomycin + Pitavastatin Moderate
- Daptomycin + Pravastatin Moderate
- Daptomycin + Rosuvastatin Moderate
Frequently asked questions
Can I take Daptomycin with Lovastatin?
MediHelp rates the interaction as moderate. Daptomycin and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Daptomycin can raise creatine phosphokinase and cause myopathy or rhabdomyolysis, and statins carry the same risk. Using both together may increase the likelihood of muscle toxicity.
How serious is the interaction between Daptomycin and Lovastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider temporarily withholding lovastatin during daptomycin therapy, especially in patients with renal impairment or other risk factors. If both are continued, monitor CPK weekly and assess for muscle pain or weakness.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
