Drug interactions
Daridorexant + Fluoxetine
Severity: Moderate
Daridorexant and Fluoxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined use can add to sedation and impair psychomotor performance and next-day alertness. Fluoxetine is a weak to moderate CYP3A4 inhibitor and could modestly raise daridorexant exposure.
What this interaction means in plain words
Daridorexant and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Fluoxetine belongs to Central Nervous System.
Why it happens
Additive CNS depression plus possible mild CYP3A4 inhibition by fluoxetine.
What to do
Use the lowest effective daridorexant dose and counsel patients about daytime drowsiness and driving. Reassess the dose if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Fluoxetine?
MediHelp rates the interaction as moderate. Daridorexant and Fluoxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combined use can add to sedation and impair psychomotor performance and next-day alertness. Fluoxetine is a weak to moderate CYP3A4 inhibitor and could modestly raise daridorexant exposure.
How serious is the interaction between Daridorexant and Fluoxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective daridorexant dose and counsel patients about daytime drowsiness and driving. Reassess the dose if excessive sedation occurs.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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