Drug interactions
Daridorexant + Hydrocodone
Severity: Moderate
Daridorexant and Hydrocodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the CNS, and combined use can increase drowsiness and impair psychomotor performance and next-day alertness. Opioid-related respiratory depression may also be worsened.
What this interaction means in plain words
Daridorexant and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Hydrocodone belongs to Musculoskeletal.
Why it happens
Additive CNS depression via opioid receptor agonism and orexin receptor antagonism.
What to do
Use the lowest effective doses and consider reducing daridorexant dose. Counsel patients about daytime impairment and avoid driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Hydrocodone?
MediHelp rates the interaction as moderate. Daridorexant and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the CNS, and combined use can increase drowsiness and impair psychomotor performance and next-day alertness. Opioid-related respiratory depression may also be worsened.
How serious is the interaction between Daridorexant and Hydrocodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and consider reducing daridorexant dose. Counsel patients about daytime impairment and avoid driving.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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