Drug interactions
Daridorexant + Imatinib
Severity: Moderate
Daridorexant and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib is a moderate CYP3A4 inhibitor and increases daridorexant exposure, which can cause next-day somnolence and impaired driving ability.
What this interaction means in plain words
Daridorexant and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Imatinib belongs to Oncology.
Why it happens
Imatinib inhibits CYP3A4 metabolism of daridorexant.
What to do
Limit daridorexant to a maximum of 25 mg per night and advise against driving if drowsiness persists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Imatinib?
MediHelp rates the interaction as moderate. Daridorexant and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib is a moderate CYP3A4 inhibitor and increases daridorexant exposure, which can cause next-day somnolence and impaired driving ability.
How serious is the interaction between Daridorexant and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit daridorexant to a maximum of 25 mg per night and advise against driving if drowsiness persists.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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