Drug interactions
Daridorexant + Lapatinib
Severity: Moderate
Daridorexant and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib may raise daridorexant concentrations by inhibiting CYP3A4, increasing next-day somnolence and impaired psychomotor performance.
What this interaction means in plain words
Daridorexant and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Lapatinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 metabolism of daridorexant by lapatinib.
What to do
Limit daridorexant to 25 mg nightly. Counsel patients on daytime drowsiness and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Lapatinib?
MediHelp rates the interaction as moderate. Daridorexant and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib may raise daridorexant concentrations by inhibiting CYP3A4, increasing next-day somnolence and impaired psychomotor performance.
How serious is the interaction between Daridorexant and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit daridorexant to 25 mg nightly. Counsel patients on daytime drowsiness and driving.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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