Drug interactions
Daridorexant + Maprotiline
Severity: Moderate
Daridorexant and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause sedation, and together they can add to impaired alertness and psychomotor performance, including next-day impairment. Falls and impaired driving are the main concerns.
What this interaction means in plain words
Daridorexant and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
Additive CNS depression from orexin receptor antagonism and the sedating antihistaminic effects of maprotiline.
What to do
Use the lowest effective daridorexant dose and counsel the patient about driving and other hazardous activities. Reassess the dose if daytime drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Maprotiline?
MediHelp rates the interaction as moderate. Daridorexant and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause sedation, and together they can add to impaired alertness and psychomotor performance, including next-day impairment. Falls and impaired driving are the main concerns.
How serious is the interaction between Daridorexant and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective daridorexant dose and counsel the patient about driving and other hazardous activities. Reassess the dose if daytime drowsiness occurs.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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