Drug interactions
Daridorexant + Metaxalone
Severity: Moderate
Daridorexant and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause central nervous system depression. Taken together they can increase drowsiness, dizziness and impairment of psychomotor performance, including next-day impairment that affects driving and falls risk.
What this interaction means in plain words
Daridorexant and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive CNS depressant pharmacodynamic effects of orexin receptor antagonism and metaxalone.
What to do
Use the lowest effective dose of each drug and counsel the patient against driving or hazardous tasks the next day. Monitor for excessive sedation, particularly in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Metaxalone?
MediHelp rates the interaction as moderate. Daridorexant and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause central nervous system depression. Taken together they can increase drowsiness, dizziness and impairment of psychomotor performance, including next-day impairment that affects driving and falls risk.
How serious is the interaction between Daridorexant and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dose of each drug and counsel the patient against driving or hazardous tasks the next day. Monitor for excessive sedation, particularly in older adults.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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