Drug interactions
Daridorexant + Valproic acid
Severity: Moderate
Daridorexant and Valproic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause central nervous system depression. Taken together, they may increase somnolence and impair next-day psychomotor performance and driving ability.
What this interaction means in plain words
Daridorexant and Valproic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Valproic acid belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects through orexin receptor antagonism and valproate sedation.
What to do
Use the lowest effective daridorexant dose and counsel patients about next-day drowsiness and driving. Reduce the dose if daytime impairment occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Valproic acid?
MediHelp rates the interaction as moderate. Daridorexant and Valproic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause central nervous system depression. Taken together, they may increase somnolence and impair next-day psychomotor performance and driving ability.
How serious is the interaction between Daridorexant and Valproic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective daridorexant dose and counsel patients about next-day drowsiness and driving. Reduce the dose if daytime impairment occurs.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
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