Drug interactions
Darifenacin + Disopyramide
Severity: Minor
Darifenacin and Disopyramide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have anticholinergic activity, so combining them can intensify dry mouth, constipation, urinary retention and blurred vision. Disopyramide is also a CYP3A4 substrate, but darifenacin is only a weak inhibitor.
What this interaction means in plain words
Darifenacin and Disopyramide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darifenacin belongs to Genitourinary; Disopyramide belongs to Cardiovascular.
Why it happens
Additive anticholinergic pharmacodynamic effects, with a minor possible pharmacokinetic contribution.
What to do
Monitor for anticholinergic effects, particularly in older patients and those with urinary retention or glaucoma. Reduce the dose if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Darifenacin
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Darifenacin with Disopyramide?
MediHelp rates the interaction as minor. Darifenacin and Disopyramide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs have anticholinergic activity, so combining them can intensify dry mouth, constipation, urinary retention and blurred vision. Disopyramide is also a CYP3A4 substrate, but darifenacin is only a weak inhibitor.
How serious is the interaction between Darifenacin and Disopyramide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects, particularly in older patients and those with urinary retention or glaucoma. Reduce the dose if symptoms occur.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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