Drug interactions
Darolutamide + Dronedarone
Severity: Moderate
Darolutamide and Dronedarone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits both P-glycoprotein and CYP3A4 and may increase darolutamide levels, possibly increasing adverse effects such as fatigue and cardiac events.
What this interaction means in plain words
Darolutamide and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darolutamide belongs to Miscellaneous; Dronedarone belongs to Cardiovascular.
Why it happens
Combined P-glycoprotein and CYP3A4 inhibition increases darolutamide exposure.
What to do
Monitor for darolutamide adverse effects and reduce the dose if poorly tolerated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Darolutamide
Frequently asked questions
Can I take Darolutamide with Dronedarone?
MediHelp rates the interaction as moderate. Darolutamide and Dronedarone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronedarone inhibits both P-glycoprotein and CYP3A4 and may increase darolutamide levels, possibly increasing adverse effects such as fatigue and cardiac events.
How serious is the interaction between Darolutamide and Dronedarone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for darolutamide adverse effects and reduce the dose if poorly tolerated.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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